Zika Virus further research & the age of open computation - boinc

Zika virus - the progress of lab based research into the worrying infection..

updating ! :  due to evidence having been found of the zika virus

https://www.newscientist.com/article/2077091-whole-zika-genome-recovered-from-brain-of-baby-with-microcephaly/

now that we have substantiated the theory that some microcephaly babies have the virus intact within the cerebellum....

the hair and nails can also be examined ...

now we know that early in womb growth of features like hair are soon replaced after the birth...

so ... what do we do ?

here are a list of avenues : suggested research platform : Blue Gene , Chines super computer , laboratories / disease control and research centres.. boinc

Boinc open gpu & cpu computing - https://boinc.berkeley.edu/

https://www.worldcommunitygrid.org is doing boinc research on zika (download boinc and join the project to help)

A : recover the placentas of infected parents .. and search for the chemical finger print of the zika..

B : we examine the size, porosity and other features of the placenta to find out if the placenta was damaged during the genesis process of the womb..

C : We examine for the damage done to cells in the foetus ... what cells exactly where infected ?

D : we examine the cellular bond sites of the zika virus so that we can find out what cells respond to the virus.

E : we will be able to see what cells where deformed by the examination of the foetus, comparing the foetus to others from the same communities & or Country/Region.

F : we compare the statistics of microcephaly in infected regions by community.. and virus infection rates/ratio..

G : we compare the microcephaly ratio to both community size and quality of life / food / hospitals & medicinal treatment.

H : carry out meaningful analyse of viral patterns for a host of global infections with mainframes and the open computer processing infrastructure.

http://esa-space.blogspot.com/2016/02/zika-virus.html (the first paper)

study into the zika virus : some updates

https://www.newscientist.com/article/2079985-zika-virus-disease-renamed-to-reflect-range-of-impacts-on-fetus/

http://www.virology.ws/2016/02/10/zika-virus-and-microcephaly/

deep study with photographic evidence

a Brazilian based study with statistical data


a few links to zika virus and pregnancy information :

http://www.cdc.gov/zika/pregnancy/

http://www.cdc.gov/zika/pregnancy/question-answers.html

http://globalnews.ca/news/2562101/heres-what-zika-virus-symptoms-look-like-in-pregnant-women/

Update 3 :

Due to the lab testing of the zika virus finding that the zika virus successfully infects brain cell precursors..
The presence of statistical evidence that indicates a significant statistical likelihood of infection by zika in mothers..
results in an increased likelihood of defects in children if infection is in the early stages of pregnancy ..
The evidence of statistical, collated evidence and lab experimentation on cells; most likely indicates to the satisfaction of science that the zika virus is most likely to cause defective babies.

The following two independent studies can be read for further details.

http://www.nejm.org/doi/full/10.1056/NEJMsr1604338 : Statistical study and examination of Zika classification as a cause of defects..

The following is a detailed study in the lab http://www.drugtargetreview.com/11438/content-type/industry-news/cdc-zika-microcephaly/

Update 4 :

Progress continues on the world community grid project for the zika virus; With over 1 million results returned,

Further research at this point is looking worthwhile

Read https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=480 for information on the project and join to add further to invention/innovation in treatment & inoculation.

& http://esa-space.blogspot.com/2017/04/boinc.html

the report on the vina boinc project for the zika viri chemical examination though computer hive proves interesting... and mentally testing/stimulating,

Showing the problems that properly optimising code for Chemical/Biological examination can face.

zika virus mutation and challenges

zika virus found to affect development - scientific america

VACCINATE !

We the people believe that inoculation is the most worthy and worthwhile solution since treatment of symptoms of illness cure too late to help the unborn child or indeed the adult in need of treatment in the case of subtle damage to the body;

(Infection and then treatment should preferably be replaced with anti viral inoculation.)

Reasoning ?

simple :

A : the patient can undergo infection with mild symptoms and still pass on the virus..

B : Medical treatment cost more and substantial portions of the native population never receive medical aid.

C : Keep cost low for N.G.O / Charities and health services..

D : Containment, vaccine's prevent host transfer of parasite & virus or germ; in most cases.

E : cope :with rising medical costs & deal with evidence from treatment versus cure...

F : work's on polio and works on other crushing insidious pests/parasites and infections.

Update 5 :

https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=584

"ultimately visually inspected the binding modes of the top 318 compounds, and we narrowed it down to 27 candidates. These candidates will be purchased and then assayed by our collaborators, to discern their potency at inhibiting the protease, as well as their efficacy in cell-based assays"

As we can see we need to recruit WHO, UN, D.W.B Doctors without boarders & generously inclined NGO generic pharmacological providers to specifically test chemicals that pass favourable HPC Experimentation at WCG to bring into form the; Compound agents into the form of administerable  medicine formula to be administered in health environments & though NGO charities aswell as agencies like the U.N.

Clearly Laboratory time is to be mandated and funded! How ? U.N, W.H.O, NGO Charitable Providers.

https://www.who.int - World Health Organisation.
https://www.msf.org/ - Médecins Sans Frontières - Doctors without borders.
https://outreach.un.org/exhibits/ - United Nations.

***

Antibody Research : (Protection is viable depends on lifetime of antibody)

Inovio : DNA-Encoded Monoclonal Antibody : Funded Fully by the Bill & Melinda Gates Foundation - Thank you Bill Gates & Melinda

http://ir.inovio.com/news-and-media/news/press-release-details/2019/Inovio-Announces-First-Subject-Dosed-with-its-DNA-Encoded-Monoclonal-Antibody-dMAb-In-First-Ever-Human-Trial/default.aspx

Immunity disorders & Illnesses may reduce efficiency .. so medicines are definitely needed for alternative paths & or price/effectiveness range,

However : "One small step for man; One giant leap for mankind"

Update 6:

Sexual Transmission:

https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/zika-virus

Stephen J. Thomas, ... Alan D. Barrett, in Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases (Eighth Edition), 2015

https://www.sciencedirect.com/science/article/pii/B9781455748013001557

David B. Huang, ... Charles D. Ericsson, in Tropical Dermatology (Second Edition), 2017

https://www.sciencedirect.com/science/article/pii/B978032329634200002X

Suggestions of intimate contact transmission : 

Jacobo Limeres Posse, ... Crispian Scully, in Saliva Protection and Transmissible Diseases, 2017
https://www.sciencedirect.com/science/article/pii/B9780128136812000044

Symptoms:

Zika Desease 2018
https://www.sciencedirect.com/science/article/pii/B978012812365200010X

"There is sufficient evidence to conclude that Zika virus not only causes congenital abnormalities and trigger Guilliain-Barre Syndrome, but it is also associated with ocular abnormalities, meningoencephalomyelitis, myelitis, and hematospermia.
Treatment and therapeutic interventions are discussed in the following chapter."

Update 7:
Zika and Dengue medicine

Dengue & Zika flaviviruses : round of compounds allowed us to select 55 new candidates for Zika and 20 candidates for dengue

The proposal is to collate the collected winning samples to categorise competing economical & efficiency solutions : Including the natural sample database..

The reasoning is : Genetic sampling & cross species variance.

https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=598

"This new round of compounds allowed us to select 55 new candidates for Zika and 20 candidates for dengue (Figure 1). The compounds were purchased and sent to the University of California in San Diego at Dr. Jair Siqueira-Neto’s laboratory, for experimental evaluation. They are performing cell-based assays in human neural stem cells (hNSCs) with ZIKV. We will also perform enzymatic assays in ZIKV NS3 helicase and protease proteins with our collaborators at the Physics Institute of Sao Carlos, University of Sao Paulo (Brazil), at Dr. Glaucius Oliva’s laboratory, to validate the predicted enzymatic candidates’ activities. "

Update 8: We need this research submitted to UN & Who : ZIKV, Dengue,Yellow fever

FAM E3 can inhibit ZIKV infection; Similar diseases, such as dengue and yellow fever,
Also utilize NS3 Helicase.. The relevance is that we know probably the compound will be usable for these dire diseases & much needed in Africa, The Middle East, Asia & other places.
We need this research submitted to UN & Who

NS3/5 : methyltransferase bound to SAH and RNA analogue

https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=630
https://www.nature.com/articles/s41598-018-24775-4

"A synthetic compound called FAM E3 can inhibit ZIKV infection by blocking the genome replication stage. Through molecular docking work on World Community Grid, the researchers were able to predict a possible interaction between FAM E3 and the ZIKV NS3 helicase & similar diseases, such as dengue and yellow fever."

Contagion: Sex & Zika https://www.nature.com/articles/s41598-019-53062-z

Location & Distribution : Brazil : https://www.nature.com/articles/s41598-017-07264-y

Profiling zika : Detection and differentiation of Zika virus
https://www.nature.com/articles/s41598-020-68635-6

Nanosensors based on LSPR are able to serologically differentiate dengue from Zika infections
https://www.nature.com/articles/s41598-020-68357-9

Continuing study GPL: Stimulating open drug discovery for SARS-CoV-2
https://www.sciencedirect.com/science/article/pii/S1359644620301458?via%3Dihub

Complete Protection in Macaques Conferred by Purified Inactivated Zika Vaccine:

https://www.nature.com/articles/s41598-020-60415-6

Virus Like Particles (VLP) as multivalent vaccine candidate against Chikungunya, Japanese Encephalitis, Yellow Fever and Zika Virus: confers resistance:

https://www.nature.com/articles/s41598-020-61103-1

Yours kindly (c) Rupert S